Protection from lethal Gram-negative bacterial sepsis by targeting Toll-like receptor 4

Toll-like receptor 4 (TLR4), the signal-transducing molecule of the LPS receptor complex, plays a fundamental role in the sensing of LPS from Gram-negative bacteria. Activation of TLR4 signaling pathways by LPS is a critical upstream event in the pathogenesis of Gram-negative sepsis, making TLR4 an...

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Dettagli Bibliografici
Autori principali: Roger, Thierry, Froidevaux, Céline, Le Roy, Didier, Reymond, Marlies Knaup, Chanson, Anne-Laure, Mauri, Davide, Burns, Kim, Riederer, Beat Michel, Akira, Shizuo, Calandra, Thierry
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2009
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650125/
https://ncbi.nlm.nih.gov/pubmed/19181857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808146106
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