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Biochemical mechanism of Acetaminophen (APAP) induced toxicity in melanoma cell lines

In this work, we investigated the biochemical mechanism of acetaminophen (APAP) induced toxicity in SK-MEL-28 melanoma cells using tyrosinase enzyme as a molecular cancer therapeutic target. Our results showed that APAP was metabolized 87% by tyrosinase at 2h incubation. AA and NADH, quinone reducin...

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Hlavní autoři: Vad, Nikhil M., Yount, Garret, Moore, Dan, Weidanz, Jon, Moridani, Majid Y.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650003/
https://ncbi.nlm.nih.gov/pubmed/18759348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.21505
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