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STRUCTURAL ANALYSIS OF FISH VERSUS MAMMALIAN HEMOGLOBINS: EFFECT OF THE HEME POCKET ENVIRONMENT ON AUTOOXIDATION AND HEMIN LOSS

The underlying stereochemical mechanisms for the dramatic differences in autooxidation and hemin loss rates of fish versus mammalian hemoglobins (Hb) have been examined by determining the crystal structures of perch, trout IV, and bovine Hb at high and low pH. The fish Hbs autooxidize and release he...

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Autors principals: Aranda, Roman, Cai, He, Worley, Chad E., Levin, Elena J., Li, Rong, Olson, John S., Phillips, George N., Richards, Mark P.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2649966/
https://ncbi.nlm.nih.gov/pubmed/18831041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.22236
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