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Allosteric Effects on Substrate Dissociation from Cytochrome P450 3A4 in Nanodiscs Observed by Ensemble and Single-Molecule Fluorescence Spectroscopy
[Image: see text] Cytochrome P450 3A4 is a major human drug-metabolizing enzyme, and displays pharmacologically-relevant allosteric kinetics caused by multiple substrate and/or effector binding. Here, in the first single-molecule fluorescence studies of CYPs, we use total internal reflection fluores...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2649694/ https://ncbi.nlm.nih.gov/pubmed/18980315 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja805772r |
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