β-Defensin-2 Protein Is a Serum Biomarker for Disease Activity in Psoriasis and Reaches Biologically Relevant Concentrations in Lesional Skin

BACKGROUND: Previous studies have extensively documented antimicrobial and chemotactic activities of beta-defensins. Human beta-defensin-2 (hBD-2) is strongly expressed in lesional psoriatic epidermis, and recently we have shown that high beta-defensin genomic copy number is associated with psoriasi...

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Detalhes bibliográficos
Main Authors: Jansen, Patrick A. M., Rodijk-Olthuis, Diana, Hollox, Edward J., Kamsteeg, Marijke, Tjabringa, Geuranne S., de Jongh, Gys J., van Vlijmen-Willems, Ivonne M. J. J., Bergboer, Judith G. M., van Rossum, Michelle M., de Jong, Elke M. G. J., den Heijer, Martin, Evers, Andrea W. M., Bergers, Mieke, Armour, John A. L., Zeeuwen, Patrick L. J. M., Schalkwijk, Joost
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2649503/
https://ncbi.nlm.nih.gov/pubmed/19266104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004725
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