β-Defensin-2 Protein Is a Serum Biomarker for Disease Activity in Psoriasis and Reaches Biologically Relevant Concentrations in Lesional Skin

BACKGROUND: Previous studies have extensively documented antimicrobial and chemotactic activities of beta-defensins. Human beta-defensin-2 (hBD-2) is strongly expressed in lesional psoriatic epidermis, and recently we have shown that high beta-defensin genomic copy number is associated with psoriasi...

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Hlavní autoři: Jansen, Patrick A. M., Rodijk-Olthuis, Diana, Hollox, Edward J., Kamsteeg, Marijke, Tjabringa, Geuranne S., de Jongh, Gys J., van Vlijmen-Willems, Ivonne M. J. J., Bergboer, Judith G. M., van Rossum, Michelle M., de Jong, Elke M. G. J., den Heijer, Martin, Evers, Andrea W. M., Bergers, Mieke, Armour, John A. L., Zeeuwen, Patrick L. J. M., Schalkwijk, Joost
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2009
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2649503/
https://ncbi.nlm.nih.gov/pubmed/19266104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004725
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