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Suppression of 2,3-Oxidosqualene Cyclase by High Fat Diet Contributes to Liver X Receptor-α-mediated Improvement of Hepatic Lipid Profile

The liver X receptors (LXRs) sense oxysterols and regulate genes involved in cholesterol metabolism. Synthetic agonists of LXRs are potent stimulators of fatty acid synthesis, which is mediated largely by sterol regulatory element-binding protein-1c (SREBP-1c). Paradoxically, an improved hepatic lip...

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Detalhes bibliográficos
Main Authors: Dang, Huaixin, Liu, Yan, Pang, Wei, Li, Chenghong, Wang, Nanping, Shyy, John Y.-J., Zhu, Yi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2649084/
https://ncbi.nlm.nih.gov/pubmed/19119143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803702200
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