Epidermal Growth Factor-like Repeats of Thrombospondins Activate Phospholipase Cγ and Increase Epithelial Cell Migration through Indirect Epidermal Growth Factor Receptor Activation

Thrombospondin (TSP) 1 is a trimeric multidomain protein that contains motifs that recognize distinct host cell receptors coupled to multiple signaling pathways. Selected TSP1-induced cellular responses are tyrosine kinase-dependent, and TSP1 contains epidermal growth factor (EGF)-like repeats. Spec...

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Bibliographische Detailangaben
Hauptverfasser: Liu, Anguo, Garg, Pallavi, Yang, Shiqi, Gong, Ping, Pallero, Manuel A., Annis, Douglas S., Liu, Yuanyuan, Passaniti, Antonino, Mann, Dean, Mosher, Deane F., Murphy-Ullrich, Joanne E., Goldblum, Simeon E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Molecular Basis of Cell and Developmental Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2649082/
https://ncbi.nlm.nih.gov/pubmed/19129184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809198200
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