Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case–control study

Functionally significant heterozygous mutations in the Melanocortin-4 receptor (MC4R) have been implicated in 2.5% of early onset obesity cases in European cohorts. The role of mutations in this gene in severely obese adults, particularly in smaller North American patient cohorts, has been less conv...

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Hlavní autoři: Calton, Melissa A., Ersoy, Baran A., Zhang, Sumei, Kane, John P., Malloy, Mary J., Pullinger, Clive R., Bromberg, Yana, Pennacchio, Len A., Dent, Robert, McPherson, Ruth, Ahituv, Nadav, Vaisse, Christian
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2009
Témata:
Association Studies Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2649015/
https://ncbi.nlm.nih.gov/pubmed/19091795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddn431
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