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Optimizing Dvl PDZ domain inhibitor by exploring chemical space
Because of advances in the high-throughput screening technology, identification of a hit that can bind to a target protein has become a relatively easy task; however, in the process of drug discovery, the following hit-to-lead and lead optimization still remain challenging. In a typical hit-to-lead...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2648812/ https://ncbi.nlm.nih.gov/pubmed/18780146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10822-008-9236-1 |
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