The COP9 Signalosome Is Required for Light-Dependent Timeless Degradation and Drosophila Clock Resetting

The ubiquitin–proteasome system plays a major role in the rhythmic accumulation and turnover of molecular clock components. In turn, these ∼24 h molecular rhythms drive circadian rhythms of behavior and physiology. In Drosophila, the ubiquitin–proteasome system also plays a critical role in light-de...

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Bibliographic Details
Main Authors: Knowles, Alyson, Koh, Kyunghee, Wu, June-Tai, Chien, Cheng-Ting, Chamovitz, Daniel A., Blau, Justin
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2648809/
https://ncbi.nlm.nih.gov/pubmed/19176824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0429-08.2009
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