THE SERINE PROTEASE MATRIPTASE-2 (TMPRSS6) INHIBITS HEPCIDIN ACTIVATION BY CLEAVING MEMBRANE HEMOJUVELIN

The liver peptide hepcidin regulates body iron, is upregulated in iron overload and inflammation and downregulated in iron deficiency/hypoxia. The transmembrane serine protease matriptase-2 (TMPRSS6) inhibits the hepcidin response and its mutational inactivation causes iron-deficient anemia in mice...

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Hauptverfasser: Silvestri, Laura, Pagani, Alessia, Nai, Antonella, De Domenico, Ivana, Kaplan, Jerry, Camaschella, Clara
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2648389/
https://ncbi.nlm.nih.gov/pubmed/18976966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2008.09.012
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