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Determinants Flanking the CD4 Binding Loop Modulate Macrophage Tropism of Human Immunodeficiency Virus Type 1 R5 Envelopes

Human immunodeficiency virus type 1 R5 viruses vary extensively in phenotype. Thus, R5 envelopes (env) in the brain tissue of individuals with neurological complications are frequently highly macrophage-tropic. Macrophage tropism correlates with the capacity of the envelope to exploit low CD4 levels...

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Autores principales: Duenas-Decamp, Maria José, Peters, Paul J., Burton, Dennis, Clapham, Paul R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2009
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2648272/
https://ncbi.nlm.nih.gov/pubmed/19129457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02133-08
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