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E4orf1 Limits the Oncolytic Potential of the E1B-55K Deletion Mutant Adenovirus

Clinical trials have shown oncolytic adenoviruses to be tumor selective with minimal toxicity toward normal tissue. The virus ONYX-015, in which the gene encoding the early region 1B 55-kDa (E1B-55K) protein is deleted, has been most effective when used in combination with either chemotherapy or rad...

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Detaylı Bibliyografya
Asıl Yazarlar: Thomas, Michael A., Broughton, Robin S., Goodrum, Felicia D., Ornelles, David A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology (ASM) 2009
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2648266/
https://ncbi.nlm.nih.gov/pubmed/19129452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01972-08
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