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E4orf1 Limits the Oncolytic Potential of the E1B-55K Deletion Mutant Adenovirus
Clinical trials have shown oncolytic adenoviruses to be tumor selective with minimal toxicity toward normal tissue. The virus ONYX-015, in which the gene encoding the early region 1B 55-kDa (E1B-55K) protein is deleted, has been most effective when used in combination with either chemotherapy or rad...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Microbiology (ASM)
2009
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2648266/ https://ncbi.nlm.nih.gov/pubmed/19129452 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01972-08 |
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