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Metronidazole lacks activity against Mycobacterium tuberculosis in an in vivo hypoxic granuloma model of latency
During human latent tuberculosis (TB) infection, dormant bacilli putatively reside within the hypoxic environment of caseating lung granulomas. The anaerobic drug metronidazole has antituberculous activity under hypoxic conditions in vitro, but lacks activity against murine TB. In this study, we use...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2647800/ https://ncbi.nlm.nih.gov/pubmed/18491971 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/589515 |
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