Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3

The Hsc/Hsp70 co-chaperones of the BAG (Bcl-2-associated athanogene) protein family are modulators of protein quality control. We examined the specific roles of BAG1 and BAG3 in protein degradation during the aging process. We show that BAG1 and BAG3 regulate proteasomal and macroautophagic pathways...

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Bibliografiska uppgifter
Huvudupphovsmän: Gamerdinger, Martin, Hajieva, Parvana, Kaya, A Murat, Wolfrum, Uwe, Hartl, F Ulrich, Behl, Christian
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2647772/
https://ncbi.nlm.nih.gov/pubmed/19229298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.29
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