Spinocerebellar ataxia type 8 larger triplet expansion alters histone modification and induces RNA foci

BACKGROUND: Spinocerebellar ataxia type 8 (SCA8) involves the expression of an expanded CTG/CAG combined repeats (CR) from opposite strands producing CUG expansion transcripts (ataxin 8 opposite strand, ATXN8OS) and a polyglutamine expansion protein (ataxin 8, ATXN8). The pathogenesis of SCA8 is com...

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Main Authors: Chen, I-Cheng, Lin, Hsuan-Yuan, Lee, Ghin-Chueh, Kao, Shih-Huan, Chen, Chiung-Mei, Wu, Yih-Ru, Hsieh-Li, Hsiu-Mei, Su, Ming-Tsan, Lee-Chen, Guey-Jen
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2009
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2647542/
https://ncbi.nlm.nih.gov/pubmed/19203395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-10-9
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