Analysis of natural variants of the hepatitis C virus internal ribosome entry site reveals that primary sequence plays a key role in cap-independent translation

The HCV internal ribosome entry site (IRES) spans a region of ∼340 nt that encompasses most of the 5′ untranslated region (5′UTR) of the viral mRNA and the first 24–40 nt of the core-coding region. To investigate the implication of altering the primary sequence of the 5′UTR on IRES activity, natural...

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Detalhes bibliográficos
Main Authors: Barría, María Inés, González, Angel, Vera-Otarola, Jorge, León, Ursula, Vollrath, Valeska, Marsac, Delphine, Monasterio, Octavio, Pérez-Acle, Tomás, Soza, Alejandro, López-Lastra, Marcelo
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2647302/
https://ncbi.nlm.nih.gov/pubmed/19106142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn1022
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