Replication at body temperature selects a neurovirulent herpes simplex virus type 2.
A prototype strain of herpes simplex virus type 2 (HG-52) replicated at 31 degrees C was avirulent when inoculated intracranially into mice. This property was not altered after serial passage of the agent at 31 degrees C, but the virus became virulent after passage at 37.5 degrees C. The selection w...
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| Udgivet i: | Infect Immun |
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| Principais autores: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology (ASM)
1983
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC264722/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6307887/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.41.2.855-857.1983 |
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