Signaling Mechanisms Mediating Muscarinic Enhancement of GABAergic Synaptic Transmission in the Spinal Cord

Activation of muscarinic acetylcholine receptors (mAChRs) inhibits spinal nociceptive transmission by potentiation of GABAergic tone through M(2), M(3), and M(4) subtypes. To study the signaling mechanisms involved in this unique mAChR action, GABAergic spontaneous inhibitory postsynaptic currents (...

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Autori principali: Zhang, Hong-Mei, Chen, Shao-Rui, Cai, You-Qing, Richardson, Timothy E., Driver, Larry C., Lopez-Berestein, Gabriel, Pan, Hui-Lin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2646800/
https://ncbi.nlm.nih.gov/pubmed/19110040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2008.11.039
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