Down-regulation of Gfi-1 expression by TGF-β is important for differentiation of Th17 and CD103(+) inducible regulatory T cells

Growth factor independent 1 (Gfi-1), a transcriptional repressor, is transiently induced during T cell activation. Interleukin (IL) 4 further induces Gfi-1, resulting in optimal Th2 cell expansion. We report a second important function of Gfi-1 in CD4 T cells: prevention of alternative differentiati...

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Detalhes bibliográficos
Main Authors: Zhu, Jinfang, Davidson, Todd S., Wei, Gang, Jankovic, Dragana, Cui, Kairong, Schones, Dustin E., Guo, Liying, Zhao, Keji, Shevach, Ethan M., Paul, William E.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2646571/
https://ncbi.nlm.nih.gov/pubmed/19188499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20081666
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