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Phosphodiester-Mediated Reaction of Cisplatin with Guanine in Oligodeoxyribonucleotides
The cancer chemotherapeutic agent cis-diamminedichloroplatinum(II) or cisplatin reacts primarily with guanines in DNA to form 1,2-Pt-GG and 1,3-Pt-GNG intrastrand cross-links, and to a lesser extent, G-G interstrand cross-links. Recent NMR evidence has suggested that cisplatin can also form a coordi...
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2646366/ https://ncbi.nlm.nih.gov/pubmed/18991396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801000w |
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