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Clinical Utility of Genotyping the 677C>T Variant of Methylenetetrahydrofolate Reductase in Humans Is Decreased in the Post-Folic Acid Fortification Era

Moderate hyperhomocysteinemia is associated with many diseases. Major factors affecting plasma total homocysteine (tHcy) concentrations include folate concentrations and polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene. Because U.S.-mandated fortification of grain products with...

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Autors principals: Tsai, Michael Y., Loria, Catherine M., Cao, Jing, Kim, Yongin, Siscovick, David, Schreiner, Pamela J., Hanson, Naomi Q.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Nutrition 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2646209/
https://ncbi.nlm.nih.gov/pubmed/19056652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3945/jn.108.096511
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