Overexpression of Carnitine Palmitoyltransferase-1 in Skeletal Muscle Is Sufficient to Enhance Fatty Acid Oxidation and Improve High-Fat Diet–Induced Insulin Resistance

OBJECTIVE—Skeletal muscle insulin resistance is associated with lipid accumulation, but whether insulin resistance is due to reduced or enhanced flux of long-chain fatty acids into the mitochondria is both controversial and unclear. We hypothesized that skeletal muscle–specific overexpression of the...

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Detalhes bibliográficos
Main Authors: Bruce, Clinton R., Hoy, Andrew J., Turner, Nigel, Watt, Matthew J., Allen, Tamara L., Carpenter, Kevin, Cooney, Gregory J., Febbraio, Mark A., Kraegen, Edward W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2009
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2646053/
https://ncbi.nlm.nih.gov/pubmed/19073774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-1078
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