m.3243A>G Mutation in Mitochondrial DNA Leads to Decreased Insulin Sensitivity in Skeletal Muscle and to Progressive β-Cell Dysfunction

OBJECTIVE—To study insulin sensitivity and perfusion in skeletal muscle together with the β-cell function in subjects with the m.3243A>G mutation in mitochondrial DNA, the most common cause of mitochondrial diabetes. RESEARCH DESIGN AND METHODS—We measured skeletal muscle glucose uptake and perfu...

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Detalhes bibliográficos
Main Authors: Lindroos, Markus M., Majamaa, Kari, Tura, Andrea, Mari, Andrea, Kalliokoski, Kari K., Taittonen, Markku T., Iozzo, Patricia, Nuutila, Pirjo
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2009
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2646052/
https://ncbi.nlm.nih.gov/pubmed/19073775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0981
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