ATR and H2AX Cooperate in Maintaining Genome Stability under Replication Stress

Chromosomal abnormalities are frequently caused by problems encountered during DNA replication. Although the ATR-Chk1 pathway has previously been implicated in preventing the collapse of stalled replication forks into double-strand breaks (DSB), the importance of the response to fork collapse in ATR...

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Detalhes bibliográficos
Main Authors: Chanoux, Rebecca A., Yin, Bu, Urtishak, Karen A., Asare, Amma, Bassing, Craig H., Brown, Eric J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2645842/
https://ncbi.nlm.nih.gov/pubmed/19049966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806739200
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