Three-dimensional modeling of and ligand docking to vitamin D receptor ligand binding domain
The ligand binding domain of the human vitamin D receptor (VDR) was modeled based on the crystal structure of the retinoic acid receptor. The ligand binding pocket of our VDR model is spacious at the helix 11 site and confined at the β-turn site. The ligand 1α,25-dihydroxyvitamin D(3) was assumed to...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2000
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26457/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10677485/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.020522697 |
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