Three-dimensional modeling of and ligand docking to vitamin D receptor ligand binding domain

The ligand binding domain of the human vitamin D receptor (VDR) was modeled based on the crystal structure of the retinoic acid receptor. The ligand binding pocket of our VDR model is spacious at the helix 11 site and confined at the β-turn site. The ligand 1α,25-dihydroxyvitamin D(3) was assumed to...

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Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Yamamoto, Keiko, Masuno, Hiroyuki, Choi, Mihwa, Nakashima, Kinichi, Taga, Tetsuya, Ooizumi, Hiroshi, Umesono, Kazuhiko, Sicinska, Wanda, VanHooke, Janeen, DeLuca, Hector F., Yamada, Sachiko
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 2000
Témata:	Biological Sciences
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26457/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10677485/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.020522697
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