Functional Analysis and Molecular Dynamics Simulation of LOX-1 K167N Polymorphism Reveal Alteration of Receptor Activity

The human lectin-like oxidized low density lipoprotein receptor 1 LOX-1, encoded by the ORL1 gene, is the major scavenger receptor for oxidized low density lipoprotein in endothelial cells. Here we report on the functional effects of a coding SNP, c.501G>C, which produces a single amino acid chan...

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Detalhes bibliográficos
Main Authors: Biocca, Silvia, Falconi, Mattia, Filesi, Ilaria, Baldini, Francesco, Vecchione, Lucia, Mango, Ruggiero, Romeo, Francesco, Federici, Giorgio, Desideri, Alessandro, Novelli, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2645694/
https://ncbi.nlm.nih.gov/pubmed/19247493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004648
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