Human aspartic protease memapsin 2 cleaves the β-secretase site of β-amyloid precursor protein

The cDNAs of two new human membrane-associated aspartic proteases, memapsin 1 and memapsin 2, have been cloned and sequenced. The deduced amino acid sequences show that each contains the typical pre, pro, and aspartic protease regions, but each also has a C-terminal extension of over 80 residues, wh...

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Cyhoeddwyd yn:	Proc Natl Acad Sci U S A
Prif Awduron:	Lin, Xinli, Koelsch, Gerald, Wu, Shili, Downs, Debbie, Dashti, Azar, Tang, Jordan
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	National Academy of Sciences 2000
Pynciau:	Biological Sciences
Mynediad Ar-lein:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26455/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10677483/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.4.1456
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