DNA instability in replicating Huntington's disease lymphoblasts

BACKGROUND: The expanded CAG repeat in the Huntington's disease (HD) gene may display tissue-specific variability (e.g. triplet mosaicism) in repeat length, the longest mutations involving mitotic (germ and glial cells) and postmitotic (neurons) cells. What contributes to the triplet mutability...

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Main Authors: Cannella, Milena, Maglione, Vittorio, Martino, Tiziana, Ragona, Giuseppe, Frati, Luigi, Li, Guo-Min, Squitieri, Ferdinando
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2645380/
https://ncbi.nlm.nih.gov/pubmed/19210789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2350-10-11
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