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Minocycline Restores Striatal Tyrosine Hydroxylase in GDNF Heterozygous Mice But Not in Methamphetamine-treated Mice

Inflammation, phospho-p38 MAP kinase activation, and a reduction in glial cell line-derived neurotrophic factor (GDNF) occur in Parkinson’s disease. Microglial activation in the substantia nigra and a tyrosine hydroxylase deficit in the striatum of 3-month-old GDNF heterozygous (GDNF(+/−)) mice were...

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Autors principals: Boger, Heather A., Middaugh, Lawrence D., Granholm, Ann-Charlotte, McGinty, Jacqueline F.
Format: Artigo
Idioma:Inglês
Publicat: 2008
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2645227/
https://ncbi.nlm.nih.gov/pubmed/19110059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2008.11.013
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