Classical complement pathway activation by antipneumococcal antibodies leads to covalent binding of C3b to antibody molecules.

We have examined whether or not a physical relationship exists between antipneumococcal antibodies (Ab) and C3b when Ab activate the classical complement pathway on the surface of pneumococci (Pn). After sensitization with 125I-labeled Ab, Pn were sequentially incubated with purified C1, C4, C2, and...

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Main Authors: Brown, E J, Berger, M, Joiner, K A, Frank, M M
Format: Artigo
Jezik:Inglês
Izdano: 1983
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC264469/
https://ncbi.nlm.nih.gov/pubmed/6642644
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