Genetic variation in the Catechol-O-Methyltransferase (COMT) gene and morphine requirements in cancer patients with pain

BACKGROUND: Genetic variation contributes to differences in pain sensitivity and response to different analgesics. Catecholamines are involved in the modulation of pain and are partly metabolized by the catechol-O-methyltransferase (COMT) enzyme. Genetic variability in the COMT gene may therefore co...

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Autori principali: Rakvåg, Trude T, Ross, Joy R, Sato, Hiroe, Skorpen, Frank, Kaasa, Stein, Klepstad, Pål
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2008
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2644687/
https://ncbi.nlm.nih.gov/pubmed/19094200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-4-64
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