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New mouse models for recessive retinitis pigmentosa caused by mutations in the Pde6a gene

The heterotetrameric phosphodiesterase (PDE) 6 complex, made up of α, β and two γ subunits, regulates intracellular cGMP levels by hydrolyzing cGMP in response to light activation of G protein coupled receptors in cones and rods, making it an essential component of the visual phototransduction casca...

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Библиографические подробности
Главные авторы: Sakamoto, Kenji, McCluskey, Michael, Wensel, Theodore G., Naggert, Jürgen K., Nishina, Patsy M.
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2009
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2644649/
https://ncbi.nlm.nih.gov/pubmed/18849587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddn327
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