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New mouse models for recessive retinitis pigmentosa caused by mutations in the Pde6a gene
The heterotetrameric phosphodiesterase (PDE) 6 complex, made up of α, β and two γ subunits, regulates intracellular cGMP levels by hydrolyzing cGMP in response to light activation of G protein coupled receptors in cones and rods, making it an essential component of the visual phototransduction casca...
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| Huvudupphovsmän: | , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Oxford University Press
2009
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2644649/ https://ncbi.nlm.nih.gov/pubmed/18849587 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddn327 |
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