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Suppression of HIV-1 Nef translation by Sam68 mutant-induced stress granules and nef mRNA sequestration
HIV-1 Nef plays important roles in HIV-1 replication and pathogenesis. It is translated from completely spliced HIV-1 RNA, its expression is inherently regulated at the levels of viral DNA transcription and RNA splicing. Here we show that Sam68 cytoplasmic mutants potently suppress Nef expression. T...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2644331/ https://ncbi.nlm.nih.gov/pubmed/19150430 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.11.024 |
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