CTLA4 blockade with ipilimumab to treat relapse of malignancy after allogeneic hematopoietic cell transplantation

Relapse of malignancy after allogeneic hematopoietic cell transplantation (allo-HCT) remains a therapeutic challenge. Blockade of the CTLA4 molecule can effectively augment antitumor immunity mediated by autologous effector T cells. We have assessed the safety and preliminary efficacy of a neutraliz...

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Hlavní autoři: Bashey, Asad, Medina, Bridget, Corringham, Sue, Pasek, Mildred, Carrier, Ewa, Vrooman, Linda, Lowy, Israel, Solomon, Scott R., Morris, Lawrence E., Holland, H. Kent, Mason, James R., Alyea, Edwin P., Soiffer, Robert J., Ball, Edward D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2009
Témata:
Transplantation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2644086/
https://ncbi.nlm.nih.gov/pubmed/18974373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-07-168468
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