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Type 5 phosphodiesterase expression is a critical determinant of the endothelial cell angiogenic phenotype

Type 5 phosphodiesterase (PDE5) inhibitors increase endothelial cell cGMP and promote angiogenesis. However, not all endothelial cell phenotypes express PDE5. Indeed, whereas conduit endothelial cells express PDE5, microvascular endothelial cells do not express this enzyme, and they are rapidly angi...

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Main Authors: Zhu, Bing, Zhang, Li, Alexeyev, Mikhail, Alvarez, Diego F., Strada, Samuel J., Stevens, Troy
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643995/
https://ncbi.nlm.nih.gov/pubmed/19028977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.90474.2008
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