Type 5 phosphodiesterase expression is a critical determinant of the endothelial cell angiogenic phenotype

Type 5 phosphodiesterase (PDE5) inhibitors increase endothelial cell cGMP and promote angiogenesis. However, not all endothelial cell phenotypes express PDE5. Indeed, whereas conduit endothelial cells express PDE5, microvascular endothelial cells do not express this enzyme, and they are rapidly angi...

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Bibliographic Details
Main Authors: Zhu, Bing, Zhang, Li, Alexeyev, Mikhail, Alvarez, Diego F., Strada, Samuel J., Stevens, Troy
Format: Artigo
Language:Inglês
Published: American Physiological Society 2009
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643995/
https://ncbi.nlm.nih.gov/pubmed/19028977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.90474.2008
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