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Type 5 phosphodiesterase expression is a critical determinant of the endothelial cell angiogenic phenotype
Type 5 phosphodiesterase (PDE5) inhibitors increase endothelial cell cGMP and promote angiogenesis. However, not all endothelial cell phenotypes express PDE5. Indeed, whereas conduit endothelial cells express PDE5, microvascular endothelial cells do not express this enzyme, and they are rapidly angi...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Physiological Society
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2643995/ https://ncbi.nlm.nih.gov/pubmed/19028977 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.90474.2008 |
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