Interleukin-10 attenuates vascular responses to endothelin-1 via effects on ERK1/2-dependent pathway

Interleukin-10 (IL-10) is an anti-inflammatory cytokine with protective actions on the vasculature. On the other hand, endothelin (ET)-1 has potent vasoconstrictor, mitogenic, and proinflammatory activities, which have been implicated in the pathophysiology of a number of cardiovascular diseases. We...

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Main Authors: Giachini, Fernanda R. C., Zemse, Saiprasad M., Carneiro, Fernando S., Lima, Victor V., Carneiro, Zidonia N., Callera, Glaucia E., Ergul, Adviye, Webb, R. Clinton, Tostes, Rita C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643883/
https://ncbi.nlm.nih.gov/pubmed/19074677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00251.2008
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