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Stability of Eukaryotic Translation Initiation Factor 4E mRNA Is Regulated by HuR, and This Activity Is Dysregulated in Cancer

Eukaryotic translation initiation factor 4E (eIF4E) is encoded by a potent oncogene which is highly elevated in many human cancers. Few studies have investigated how the level, and thus activity, of eIF4E is regulated in healthy (noncancerous) cells and how they become elevated in malignant cells. H...

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Main Authors: Topisirovic, Ivan, Siddiqui, Nadeem, Orolicki, Slobodanka, Skrabanek, Lucy A., Tremblay, Mathieu, Hoang, Trang, Borden, Katherine L. B.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology (ASM) 2009
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643828/
https://ncbi.nlm.nih.gov/pubmed/19114552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01532-08
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