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Nuclear Export of NBN Is Required for Normal Cellular Responses to Radiation
Nijmegen breakage syndrome arises from hypomorphic mutations in the NBN gene encoding nibrin, a component of the MRE11/RAD50/nibrin (MRN) complex. In mammalian cells, the MRN complex localizes to the nucleus, where it plays multiple roles in the cellular response to DNA double-strand breaks. In the...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2643806/ https://ncbi.nlm.nih.gov/pubmed/19075003 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01131-08 |
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