Expression of vFLIP in a Lentiviral Vaccine Vector Activates NF-κB, Matures Dendritic Cells, and Increases CD8(+) T-Cell Responses

Lentiviral vectors deliver antigens to dendritic cells (DCs) in vivo, but they do not trigger DC maturation. We therefore expressed a viral protein that constitutively activates NF-κB, vFLIP from Kaposi's sarcoma-associated herpesvirus (KSHV), in a lentivector to mature DCs. vFLIP activated NF-...

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Detalhes bibliográficos
Main Authors: Rowe, Helen M., Lopes, Luciene, Brown, Najmeeyah, Efklidou, Sofia, Smallie, Timothy, Karrar, Sarah, Kaye, Paul M., Collins, Mary K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643792/
https://ncbi.nlm.nih.gov/pubmed/19036811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00709-08
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