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The Human Immunodeficiency Virus Type 1 Envelope Spike of Primary Viruses Can Suppress Antibody Access to Variable Regions

The human immunodeficiency virus type 1 (HIV-1) envelope spike is a heavily glycosylated trimeric structure in which protein surfaces conserved between different HIV-1 isolates are particularly well hidden from antibody recognition. However, even variable regions on the spike tend to be less antigen...

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Main Authors: Pantophlet, Ralph, Wang, Meng, Aguilar-Sino, Rowena O., Burton, Dennis R.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology (ASM) 2009
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גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643787/
https://ncbi.nlm.nih.gov/pubmed/19036813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02046-08
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