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Tight Junction Proteins Claudin-1 and Occludin Control Hepatitis C Virus Entry and Are Downregulated during Infection To Prevent Superinfection

A tight junction (TJ) protein, claudin-1 (CLDN1), was identified recently as a key factor for hepatitis C virus (HCV) entry. Here, we show that another TJ protein, occludin, is also required for HCV entry. Mutational study of CLDN1 revealed that its tight junctional distribution plays an important r...

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Opis bibliograficzny
Główni autorzy: Liu, Shufeng, Yang, Wei, Shen, Le, Turner, Jerrold R., Coyne, Carolyn B., Wang, Tianyi
Format: Artigo
Język:Inglês
Wydane: American Society for Microbiology (ASM) 2009
Hasła przedmiotowe:
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643775/
https://ncbi.nlm.nih.gov/pubmed/19052094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01888-08
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