ISG15 Arg151 and the ISG15-Conjugating Enzyme UbE1L Are Important for Innate Immune Control of Sindbis Virus

Interferon (IFN)-stimulated gene 15 (ISG15) is a ubiquitin-like molecule that conjugates to target proteins via a C-terminal LRLRGG motif and has antiviral function in vivo. We used structural modeling to predict human ISG15 (hISG15) residues important for interacting with its E1 enzyme, UbE1L. Kine...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Giannakopoulos, Nadia V., Arutyunova, Elena, Lai, Caroline, Lenschow, Deborah J., Haas, Arthur L., Virgin, Herbert Whiting
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology (ASM) 2009
Pynciau:
Pathogenesis and Immunity
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643764/
https://ncbi.nlm.nih.gov/pubmed/19073728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01590-08
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