Mice Lacking the ISG15 E1 Enzyme UbE1L Demonstrate Increased Susceptibility to both Mouse-Adapted and Non-Mouse-Adapted Influenza B Virus Infection

ISG15 functions as a critical antiviral molecule against influenza virus, with infection inducing both the conjugation of ISG15 to target proteins and production of free ISG15. Here, we report that mice lacking the ISG15 E1 enzyme UbE1L fail to form ISG15 conjugates. Both UbE1L(−/−) and ISG15(−/−) m...

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Main Authors: Lai, Caroline, Struckhoff, Jessica J., Schneider, Jana, Martinez-Sobrido, Luis, Wolff, Thorsten, García-Sastre, Adolfo, Zhang, Dong-Er, Lenschow, Deborah J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2009
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2612374/
https://ncbi.nlm.nih.gov/pubmed/19004958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00105-08
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