Protective HLA Class I Alleles That Restrict Acute-Phase CD8(+) T-Cell Responses Are Associated with Viral Escape Mutations Located in Highly Conserved Regions of Human Immunodeficiency Virus Type 1

The control of human immunodeficiency virus type 1 (HIV-1) associated with particular HLA class I alleles suggests that some CD8(+) T-cell responses may be more effective than others at containing HIV-1. Unfortunately, substantial diversities in the breadth, magnitude, and function of these response...

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Detalhes bibliográficos
Main Authors: Wang, Yaoyu E., Li, Bin, Carlson, Jonathan M., Streeck, Hendrik, Gladden, Adrianne D., Goodman, Robert, Schneidewind, Arne, Power, Karen A., Toth, Ildiko, Frahm, Nicole, Alter, Galit, Brander, Christian, Carrington, Mary, Walker, Bruce D., Altfeld, Marcus, Heckerman, David, Allen, Todd M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643763/
https://ncbi.nlm.nih.gov/pubmed/19036810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01061-08
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