Pore-Forming Activity of Alpha-Toxin Is Essential for Clostridium septicum-Mediated Myonecrosis

Clostridium septicum alpha-toxin is a β-barrel pore-forming cytolysin that is functionally similar to aerolysin. Residues important in receptor binding, oligomerization, and pore formation have been identified; however, little is known about the activity of the toxin in an infection, although it is...

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Bibliografiske detaljer
Main Authors: Kennedy, Catherine L., Lyras, Dena, Cordner, Leanne M., Melton-Witt, Jody, Emmins, John J., Tweten, Rodney K., Rood, Julian I.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2009
Fag:
Molecular Pathogenesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643643/
https://ncbi.nlm.nih.gov/pubmed/19139192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01267-08
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