Stromal control of oncogenic traits expressed in response to overexpression of GLI2, a pleiotropic oncogene

Hedgehog signaling is often activated in tumors, yet it remains unclear how GLI2, a transcription factor activated by this pathway, acts as an oncogene. We show that GLI2 is a pleiotropic oncogene. Overexpression induces genomic instability and blocks differentiation, likely mediated in part by enha...

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Hlavní autoři: Snijders, Antoine M., Huey, Bing, Connelly, S. Thaddeus, Roy, Ritu, Jordan, Richard C. K., Schmidt, Brian L., Albertson, Donna G.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643346/
https://ncbi.nlm.nih.gov/pubmed/19015636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2008.421
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